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KMID : 0942820120110020088
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Journal of Korean Brain Tumor Society
2012 Volume.11 No. 2 p.88 ~ p.95
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Chromosomal Karyotype of Malignant Gliomas : Its Relationship with Radiological Features and Prognosis
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Yu Jae-Won
Kim Young-Zoon
Song Young-Jin
Kim Dae-Cheol
Han Jin-Yeong
Kim Ki-Uk
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Abstract
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Objectives: Numerous genetic alterations are related to tumorigenesis and influence the radiological features of malignant glial tumor. We performed a cytogenetic analysis from a fresh tumor specimen and analyzed its relationship with radiological features and prognosis.
Materials and Methods: Among the 29 patients with malignant glial tumor involved in cytogenetic analysis, 19 cases showing chromosomal abnormality were analyzed. Cytogenetic analysis was performed with pathologically proven fresh surgical specimen. Both medical records and radiological findings were reviewed to define the tumor, to evaluate peritumoral edema and to assess treatment results.
Results: The most frequent genetic abnormality was observed in chromosome 7 (57.8 %). Complex karyotype presenting three or more abnormalities was noted in 11 cases (57.8 %). Chromosomal abnormalities, noted in more than three cases, were whole loss of Y (7 cases), whole gain of 7 (6 cases), whole gain of 2, whole gain of 5, whole gain of 12, 19q gain, 6p loss, 9p loss, and whole gain of 13 (3 cases). We reported that loss of chromosome 7 related to MDR-1 (Multidrug resistant gene) were correlated with good response of chemotherapy.
Conclusions: A chromosomal analysis of malignant glioma can be perfomed to discover tumorigenic factors and to evaluate radiological features. Results of karyotyping is closely related to the clinical outcome and may be utilized in developing new therapeutic modalities.
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KEYWORD
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Chromosome, Glioblastoma, Karyotype, Malignant glioma, MMP, Prognosis
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